Proteasome regulates platelet life span 1 Regulatory role of proteasome in determination of platelet life span*
نویسندگان
چکیده
Background: The molecular players regulating platelet life span are largely unexplored. Results: Proteasome inhibition induced apoptotic changes in platelets associated with rise in active Bax and significant drop in platelet life span. Conclusion: Proteasome plays crucial role in delimiting platelet life span through constitutive elimination of the conformationally active Bax. Significance: The findings bear relevance in clinical settings where proteasome is therapeutically inhibited.
منابع مشابه
Regulatory role of proteasome in determination of platelet life span.
Limit of platelet life span (8-10 days) is determined by the activity of a putative "internal clock" composed of Bcl-2 family proteins, whereas the role of other molecular players in this process remains obscure. Here, we sought to establish a central role of proteasome in platelet life span regulation. Administration of mice with inhibitors of proteasome peptidase activity induced significant ...
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